Evaluation of Presepsin as a Predictive Marker in Women Undergoing ICSI


  •   Bushra Rasheed Al-Azawea

  •   Hayder A. L. Mossa

  •   Liqaa R. Altamimi

  •   Lubna Amer Al-Anbary


Purpose: The purpose of this study was to determine the ability of using Presepsin as a biomarker to evaluate the clinical pregnancy rate in a cohort of couples undergoing ICSI in a sample of Iraqi population.

Patients and Methods: Sixty infertile women selected for undergoing intracytoplasmic sperm injection, the patient’s ovarian stimulation were by antagonist protocol accordingly to their clinical findings.

Results: The results of the study shows there was no significant difference in the serum Presepsin between pregnant and non-pregnant ladies, 421.57 (1534.65) versus 878.64 (1322.23), respectively (P = 0.875), Furthermore, there was no significant difference in follicular fluid Presepsin between pregnant and non-pregnant ladies, 1286.73 (1232.00) versus 0.00 484.15 (1467.00), respectively (P = 0.296).

Conclusions :We conclude that serum or follicular fluid Presepsin as a biomarker is a poor predictor of fertility outcome with no significant difference between pregnant and non-pregnant ladies


Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, Sullivan E, van der Poel S. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology. Fertil Steril, 2009;92: 1520-4.

Turchi, P. ‘Prevalence, Definition and Classification of Infertility’ in Clinical Management of Male Infertility, 2014; 20: 5-11.

De Roux, N. Dodé, C. ‘Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism-pathogenesis, diagnosis and treatment’, National Review of Endocrinogyl, Sep 2015; 11(9): 547-64.

Mussap M, Noto A, Fravega M, Fanos V. Soluble CD14 subtype Presepsin (sCD14-ST) and lipopolysaccharide binding protein (LBP) in neonatal sepsis: New clinical and analytical perspectives for two old biomarkers. J Matern Fetal Neonatal Med. 2011; 24:12–14.

Yaegashi Y, Shirakawa K, Sato N, Suzuki Y, Kojika M, Imai S, Takahashi G, Miyata M, Furusako S, Endo S. Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemother. 2005; 11:234–238.

Rey Nores JE, Bensussan A, Vita N, Stelter F, Arias MA, Jones M, Lefort S, Borysiewicz LK, Ferrara P, Labéta MO. Soluble CD14 acts as a negative regulator of human T cell activation and function. Eur J Immunol. 1999; 29:265–276.

Levin I, Gamzu R, Mashiach R, Lessing JB, Amit A, Almog B. Higher C-Reactive protein levels during IVF stimulation are associated with ART failure. J Reprod Immunol. 2007; 75:141–144.

Seckin B, Ozaksit G, Batioglu S, Ozel M, Aydoğan M, Senturk B. The relationship between the change in serum high sensitivity C-reactive protein levels and IVF success. Gynecol Endocrinol. 2012; 28:418–421.

Asma Z. Fadhil, Thuraya Husamaldeen Abdullah, Hayder Ali Lafta Mossa. Evaluation of the effectiveness of transvaginal ovarian drilling under ultrasound guide in patients with resistant polycystic ovary syndrome to clomiphene citrate. International Journal of Research in Pharmaceutical Sciences (2019)., 10(2), 1556-1561.

Fatimah Abdulrazaq Raheem, Hayder A. L. Mossa, Wasan A. Abdulhamed, Liqaa R. Altamimi. Assessment of Oxidative Stress Changes in Serum and Follicular Fluid in Relevance to GnRH Rival Protocol in Iraqi Infertile Ladies Undergoing ICSI. European Journal of Medical and Health Sciences (2019),1(5)1-5.

Hussain SS, Al-Murshidi SY, Al-Fatlawi SJ. Association of Endometrial Thickness with Pregnancy Rate in Infertile Women Undergoing ICSI Program. International Journal of Pharmaceutical Research and Allied Sciences. 2018; 7(3):166-171.

Ahmeid MS. Correlation between follicular fluid leptin and the pregnancy rate in women who underwent ICSI. International Journal of Current Research. 2015; 7(12): 24274-24277.

Fadhil SS., Selman MO., Al-Obaidi MT. Study the Number of Transferred Embryos Increase the Pregnancy Rates in Fresh ICSI-ET-cycles. Global Journal of Bioscience and Biotechnology. 2017; 6 (4): S1-S5.

Ashrafi M, Jahanian Sadatmahalleh S, Akhoond MR, Ghaffari F, Zolfaghari Z. ICSI Outcome in Infertile Couples with Different Causes of Infertility: A Cross-Sectional Study. Int J Fertil Steril. 2013;7(2):88–95.

Eftekhar M, Mohammadian F, Yousefnejad F, Molaei B, Aflatoonian A. Comparison of conventional IVF versus ICSI in non-male factor, normoresponder patients. Iran J Reprod Med. 2012;10(2):131–136.

Zagadailov P, Hsu A, Seifer DB, Stern JE. Differences in utilization of Intracytoplasmic sperm injection (ICSI) within human services (HHS) regions and metropolitan megaregions in the U.S. Reprod Biol Endocrinol. 2017;15(1):45.

Ovayolu A, Özdamar Ö, Gün İ, et al. Can blood or follicular fluid levels of Presepsin predict reproductive outcomes in ART: a preliminary study. Int J Clin Exp Med. 2015;8(5):7983–7988.

Ovayolu A, Özdamar Ö, Gün İ, et al. The assesment of follicular fluid Presepsin levels in poor ovarian responder womenandits relationship with the reproductive outcomes. Int J Clin Exp Med. 2015;8(6):9961–9966.

Seckin B, Ozaksit G, Batioglu S, Ozel M, Aydoğan M, Senturk B. The relationship between the change in serum high sensitivity C-reactive protein levels and IVF success. Gynecol Endocrinol. 2012; 28:418–421.

Almagor M, Hazav A, Yaffe H. The levels of C-reactive protein in women treated by IVF. Hum Reprod. 2004; 19:104–106.

Orvieto R, Chen R, Ashkenazi J, Ben-Haroush A, Bar J, Fisch B. C-Reactive protein levels in patients undergoing controlled ovarian hyperstimulation for IVF cycle. Hum Reprod. 2004; 19:357–359.

Wunder DM, Kretschmer R, Bersinger NA. Concentrations of leptin and C-reactive protein in serum and follicular fluid during assisted reproductive cycles. Hum Reprod. 2005; 20:1266–1271.


How to Cite
Al-Azawea, B. R., Mossa, H. A. L., Altamimi, L. R., & Al-Anbary, L. A. (2020). Evaluation of Presepsin as a Predictive Marker in Women Undergoing ICSI. European Journal of Biology and Biotechnology, 1(6). https://doi.org/10.24018/ejbio.2020.1.6.116