Laboratory Findings, Vaginal Cytology and Histopathology in Bitches with Cystic Endometrial Hyperplasia – Pyometra Complex


  •   Martin Llazani

  •   Alketa Qoku

  •   Luljeta Dhaskali


Cystic Endometrial Hyperplasia -Pyometra complex, a common pathological condition of uterus in bitches, it is attributed hormonal and bacteriological causes. It is studied in 10 bitches of cross and pure bred and aged from 1-13 years. In this study, the average age of animals was 8.33±1 year. Hematological and biochemical lab findings were evaluated in bitches with or without vaginal discharge. Lab findings were leukocytosis, neutrophilia and normocytic, normocromic anemia. Biochemical results shown increased of ALT and ALKP and a moderate of BUN. An increased number of parabasal and intermediate cells were detected in vaginal cytology. Histopathologic diagnosis confirmed thickness of uteri wall, a lot of cystic glands of it and the pus presented in lumen of uterus and its horns.

The purposes of this study were that through different techniques to diagnose earlier Cystic Endometrial Hyperplasia – Pyometra complex in bitches, in order to welfare of animals.

Keywords: Bitches, CEH-Pyometra Complex, cytology, histopathology


B. A., Fransson. “Systemic Inflammatory Response in Canine Pyometra”. Doctoral Thesis. Acta Universitatis Agriculturae Sueciae, Veterinaria 161, pp. 48. 2003.

B. Kempisty, D. Bukowska, M. Wozna, H. Piotrowska, M. Jackowska, A. Zuraw, S. Ciesiolka, P. Antosik, H. Maryniak, E. Ociepa, Sz. Porowski, K.P. Brussow, J.M. Jaskowski, M. Nowicki 2013. “Endometritis and pyometra in bitches: A review”. Veterinarni Medicina, vol. 58 (6), pp. 289–297, 2013.

B. L. Hamm, J. Dennis. “Canine pyometra. Early recognition and diagnosis”. Veterinary Medicine. May 01, 2012.

B. Maddens, R. Heiene, P. Smets, M. Svensson, L. Aresu, J. van der Lugt, S. Daminet, E. Meyer. “Evaluation of kidney injury in dogs with pyometra based on proteinuria, renal histomorphology, and urinary biomarkers”. J Vet Intern Med, vol. 25, pp. 1075–1083, 2011.

Bigliardi and Pamigiani. “Ultrasonography and Cystic Hyperplasia-Pyometra Complex in the Bitch”. Reproduction in Domestic Animals, 2004 Blackwell Verlag, Berlin, 2004, ISSN 0936-6768.

C. Dow. “Experimental reproduction of cystic endometrial-pyometra complex in the bitch”. J Pathol Bacteriol, vol. 78: pp. 267–79, 1959.

E. C. Feldman, R. W. Nelson. “Canine and Feline Endocrinology and Reproduction”, Ed Pedersen, Saunders, Philadelphia, pp. 525-548, 1987.

E. C. Feldman, R. W. Nelson. “Cystic endometrial hyperplasia/pyometra complex”. In: Canine and feline endocrinology and reproduction. 3rd ed. St. Louis, Mo: Saunders, pp. 852-867, 2004.

G. A. L. Veiga, R. H. Miziara, D. Souza Ramos Angrimani, P. Carvalho Papa, B. Cogliati, C. Infantosi Vannucchi. “Cystic endometrial hyperplasia–pyometra syndrome in bitches: identification of hemodynamic, inflammatory, and cell proliferation change”. Biology of Reproduction, vol. 96(1): pp. 58–69, 2017.

H. De Bosschere, R. Ducatelle, H. Vermeirsch, W. Van Den Broeck, Coryn M. “Cystic endometrial hyperplasia-pyometra complex in the bitch: should the two entities be disconnected?” Theriogenology, vol. 55: pp. 1509–19, 2001.

J. Verstegen, G. Dhaliwal, K. Verstegen-Onclin. “Mucometra, cystic endometrial hyperplasia, and pyometra in the bitch: Advances in treatment and assessment of future reproductive success”. Theriogenology, vol. 70:364–374, 2008.

K. V. F. Jubb, P. C. Kennedy, R. B. Miller. Pathology of Domestic Animals, Eds Jubb, Kennedy & Palmer, 4th edn, 2003. pp382-384, Academic Press, San Diego.

M. Llazani, A. Qoku, L.Dhaskali. Ultrasonographic diagnosis of pyometra on bitches: a preliminary study. Veterinary Medicine 2021, May 26-27, 2021, Dublin, Ireland.

M. Woźna-Wysocka, M. Rybska, B. Błaszak, B. M. Jaśkowski, M. Kulus. “Morphological Markers of Pathological Changes in Bitches Endometrium Affected by a Cystic Endometrial Hyperplasia – Pyometra Complex (CEH-P)”. 2020. DOI:10.21203/

R Hagman. “Clinical and Molecular Characteristics of Pyometra in Female Dogs” Reprod Dom Anim 47, vol. 6 323–325, 2012. doi: 10.1111/rda.12031 ISSN 0936–6768).

R. Hagman, H. Kindahl, A. S. Lagerstedt. “Pyometra in bitches induces elevated plasma endotoxin and prostaglandin F2a metabolite levels”. Acta Vet Scand. vol. 47: pp. 55. 2006.

R. W. Nelson, E. C. Feldman. “Pyometra”. Vet Clin N Am Small Anim Pract, vol. 16: pp. 561. (1986). doi: 10.1016/s0195-5616(86)50061-9.

S. D. Johnston, M. V. R. Kustritz, P. N. S. Olson. “Canine and Feline”. Theriogenology, Ed Kersey, pp 463-471, Saunders, Philadelphia, 2001.


How to Cite
Llazani, M., Qoku, A., & Dhaskali, L. (2021). Laboratory Findings, Vaginal Cytology and Histopathology in Bitches with Cystic Endometrial Hyperplasia – Pyometra Complex. European Journal of Biology and Biotechnology, 2(3), 61-63.